free radicals cause dna damage.

How Free Radicals Damage Our Bodies

Reading Time: 5 minutes. >>

Summary: Here’s what researchers have discovered about stopping the destruction caused by free radicals, including DNA damage, macromolecular damage, and damage to mitochondrial DNA. [This article first appeared on the website LongevityFacts.com. Author: Brady Hartman. ]

Scientists widely believe that DNA damage and macromolecular damage caused by free radicals generated by our mitochondria is the principle cause of aging.

However, they may have found a way to stop it.

Free Radicals and DNA Damage

Free radicals are the principal cause of DNA damage, and our bodies generate them every minute in every one of our cells. Free radicals are members of a family known as reactive oxygen species (ROS). The ROS family includes free radicals, as well as other damaging molecules such as hydrogen peroxide.

Free Radical Theory Of Aging

The idea that free radicals cause aging was proposed by Leo Szilard in a 1959 paper, who argued that free radicals cause DNA damage. The free radical theory has been superseded by modern damage theories, such as the network theory of aging which goes hand-in-hand with the disposable soma theory of aging that proposes evolutionary forces are behind the aging process.

Szilard’s paper led to the current widespread view that DNA damage and other macromolecular damage are principal causes of aging for most animals. Szilard said this damage accumulated as the result of lifelong exposure to ionizing radiation as well as free radicals and other toxins.

When not repaired, this damage accumulates, leading to mutations in our nuclear DNA, mitochondrial DNA as well as our epigenome. The damage caused by ROS, toxins, injuries and other and other assaults is cumulative and causes disease, aging and probably even cancers.

High Rate of DNA Damage

This DNA damage occurs daily at a remarkable rate. Moreover, mistakes happen when our cells divide. At the same time, another type of damage occurs that needs to be repaired as well. The net result is that our cellular repair mechanisms get overwhelmed. The combined stresses cause breaks in our DNA. Each time a cell divides, it has about 50 breaks or so. Added to this are thousands of assaults that every cell receives every day of its existence.

The cell makes mistakes carrying out these repairs, introducing epigenetic alterations that can persist after the repairs are completed. The epigenome incurs changes called epimutations, as a result of DNA methylation, or modifications in histones, the spools around which DNA wind.  As Jim Mellon and Al Chalabi (M+C), authors of the book, Juvenescence put it,

“aggregation of unrepaired DNA causes genome-wide epigenetic change over time,”

The authors go on to say that

“It is now thought by some eminent scientists that if the repair process of DNA could be enhanced, then the build-up of such epigenetic change could be reversed or at least slowed.”

Free Radicals and Mitochondria

We all need to breathe, and our mitochondria produce reactive oxygen species when they process oxygen. Our mitochondria carry out a process called aerobic respiration that sometimes produces partly-metabolized oxygen, the cause of free radicals. Free radicals, are molecules with unpaired electrons and cause damage by stealing electrons from their neighbors. These free radicals create a multitude of macromolecular damage, including damage to mitochondrial DNA (mtDNA), nuclear DNA and surrounding structures.

Researchers have long known that dysfunctional mitochondria cause aging. Free radicals cause damage to our mitochondrial DNA, which in turn causes ill health and accelerates the aging process. Scientists have known for some time that mitochondria play a role in cancer.  Researchers also agree that damaged mitochondria contribute to the chronic conditions of aging, including type 2 diabetes, heart disease, Parkinson’s and Alzheimer’s disease.

Mitochondrial Dysfunction With Age

Mitochondrial dysfunction is one of the nine hallmarks of aging. As we get older, our mitochondria decline both in quality and quantity. Researchers suspect this decline is partially responsible for a general overall deterioration, including areas such as endurance, hearing, intellect, and lower muscle strength.

Not only does the quantity of our mitochondria decline as we age, but the remaining ones become less efficient and generate less energy while producing more toxic reactive oxygen species. As we age, our cell is making less anti-oxidant defenses. Free radicals are not a problem for young people whose bodies manufacture plenty of anti-oxidants, but as our defenses decline in old age, oxidative damage takes a toll on our cells.

Antioxidants and Free Radicals

The body has natural antioxidants that usually mop up free radicals before they do any damage. These antioxidants include superoxide dismutase (SOD), catalase, and glutathione peroxidase. As authors M+C put it,

“However, this chemical security force can and does fail to disarm all the free radicals that the cell makes. And it is because some ROS evade antioxidants that genetic mutations, damage to our lipids (fats) and damage to our proteins start to occur.”

When we are young, our bodies have plenty of these antioxidants and in the 1980’s and 1990’s proponents of the free radical theory of aging advocated taking antioxidant supplements to ward off the damage.

While the body’s natural antioxidant molecules quench free radicals, these aren’t the bad guys they were once portrayed to be. Free radicals have multiple roles within the cell, sometimes beneficial, at other times destructive. As M+C point out,

“Intriguingly, it is now pretty certain that many antioxidant supplements play no, or little, positive role in preventing this type of damage.”

Calorie Restriction Fights Free Radicals

Antioxidant supplements seem to offer little protection against damage from reactive oxygen species. M+C suggest that calorie restriction or intermittent fasting protects our bodies against these free radicals, saying

“calorie restriction (CR) is a mild positive stressor for our cells and seems to stimulate the body’s production of natural antioxidants. ”

Bottom Line

Unfortunately, calorie restriction is hard for people to practice and that’s why researchers have come up with drugs that mimic its effects, most notably rapamycin. The drug doesn’t necessarily quench free radicals. However, research says it speeds up the cellular housekeeping service known as autophagy.

Show Us Some Love

  • Share this post on social media and help us spread the word–  It only takes one click on any of the social media links on this page.
  • Follow us on social media –  Google+ or Reddit
  • Sign up for our email list – We use your email to notify you of new articles. We will not send you spam, and we will not share your email address. You can cancel at any time.
  • Tell us what you think  – Scroll down to enter your comments below.

References

Cover photo: Getty Images.

Gladyshev, Vadim N. “The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!” Antioxidants & Redox Signaling 20.4 (2014): 727–731. PMC. Web. 7 Jan. 2018. Article Link.

Jim Mellon, Al Chalabi. Juvenescence: Investing in the age of longevity. 1st Edition. Harriman House. ISBN(s): 9780993047817 – 9780993047824, 25th Sep 2017. Link.

Park CB, Larsson NG. Mitochondrial DNA mutations in disease and aging. Journal of Cell Biology 2011;193:809–818.

Alexeyev, M., Shokolenko, I., Wilson, G., and LeDoux, S.  The maintenance of mitochondrial DNA integrity—critical analysis and update. (2013). Cold Spring Harbor perspectives in biology, 5(5), a012641.

Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database of Systematic Reviews 2012, Issue 3. Art. No.: CD007176. DOI: 10.1002/14651858.CD007176.pub2. Article Link.

Disclaimer

Diagnosis, Treatment, and Advice:  This article is intended for educational and informational purposes only and is not a substitute for qualified, professional medical advice.  The information and opinions provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Consult a qualified and licensed physician for the diagnosis and treatment of any and all medical conditions. Experimental diabetes treatments carry a much higher risk than FDA-approved ones. Call 911, or an equivalent emergency hotline number, for all medical emergencies. As well, consult a licensed, qualified physician before changing your diet, supplement or exercise programs.
Photos, Endorsements, & External Links:  This article is not intended to endorse organizations, companies, or their products. Links to external websites, mention or depiction of company names or brands, are intended for illustration only and do not constitute endorsements.

4 Replies to “How Free Radicals Damage Our Bodies”

  1. Sorice Madina

    Around age 60 I noticed that my handwriting was getting smaller and I was writing faster. I also noticed a small tremor in my right hand. The doctor went over my different symptoms and he suspected I’d either had a small stroke or the beginnings of Parkinson ‘s disease. After finding a neurologist and some testing I was diagnosed with the beginning stages of Parkinson’s disease. That was 4 years ago. I take Sinimet four times a day to control my symptoms, which include falling, imbalance, gait problems, swallowing difficulties, and slurring of speech,

Comment? Tell us what you think using your Twitter, Facebook, or Google+ account.